This herbaceous perennial typically grows in colonies from a single root in open deciduous forests and shady fields, riverbanks and roadsides. The solution is left on the warts for 1 to 6 hours, and then washed off. The amount of resin and podophyllum toxin is greater in indian podophyllum. Mayapple, podophyllum peltatum master gardener program. Consider appropriate extinguishing media for surrounding fire. Nov 15, 2018 podocon25 is composed of podophyllin podophyllum resin, american 25% in benzoin tincture. Podophyllum resin topical is for use only on the skin. Podophyllum resin is made from the extracts of certain plants such as american mandrake, may apple, ducks foot, indian apple. Podophyllum peltatum, commonly called mayapple, is a rhizomatous, native missouri wildflower that occurs in both moist and dry woodland areas throughout the state. A case of podophyllum poisoning with involvement of the nervous system. Treatment of basal cell carcinoma by topical 25% podophyllin solution. Podophyllum resin topical for the skin is used to treat genital and anal warts in adults.
Podophyllum l an endergered and anticancerous medicinal. Podophyllum resin poisoning with complete recovery jama. Podophyllum resin is the powdered mixture of resins removed from the may apple or mandrake podophyllumpeltatumlinne, a perennial plant of northern and middle united states 1. Remove breathing apparatus only after contaminated clothing have been completely removed. It appears worthwhile to report our case because of the complete recovery of our patient. Other research shows that adding acyclovir cream to 25% podophyllum resin is more effective than the 25% podophyllum resin alone for treating oral leukoplakia. This natural product has been also isolated from podophyllum emodi indian podophyllum ramos et al.
A solution is prepared by forming a paste with benzoin in alcohol. Immediately remove any clothing soiled by the product. This medicine is a liquid that is put on the skin to treat warts. Podophyllum resin, topical tufts medical center community care. Early research suggests that a single application of 25% podophyllum resin in tincture of benzoin to the affected area can help heal wounds caused by hairy leukoplakia. Working with or exposure to certain epoxies or resins could increase your chances of having fertility problems, miscarriage, stillbirth, or a baby with birth defects. It is a very unique plant that has two leaves when it produces a flower under the leaves, and has only one leaf when it does not produce flower. Podophyllum resin topical for the skin is used to treat genital. The one remaining species is podophyllum peltatum, with common names mayapple, american mandrake, wild mandrake, and ground lemon.
For the removal of benign epithelial growths such as venereal warts condylomata acuminata, common warts verruca vulgaris, and benign papillomas such as granuloma inguinale and plantar warts. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Dailymed cantharidin 1% podophyllum resin 5% salicylic. Usp 38 tests requirement result unit standard remark appearance fine, slightly brown to dark brown or green yellow powder conform identification a conform conform. Initially, podophyllum should be left in contact for no more than 30 to 40 minutes to determine patient sensitivity. Podophyllin resin is used for the treatment of condylomata accuminata. Podophyllum and benzoin are skin, eye, and mucous membrane irritants. The plants are sometimes included in the family berberidaceae. It forms dense colonies in open deciduous woodlands and other shaded sites. Benzoin tincture may be harmful by ingestion, inhalation or skin absorption. This is a shade loving, clumpforming perennial that typically grows to 1824 tall. Keep it away from the mouth because it is harmful if swallowed. Get a printable copy pdf file of the complete article 866k, or click on a page image below.
Join our friendly community that shares tips and ideas for gardens, along with seeds and plants. Podophyllum resin topical advanced patient information. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Production of podophyllotoxin from podophyllum hexandrum. Podophyllum resin, usp is used as a medication to treat genital warts and plantar warts. Podophyllotoxin acts as an inhibitor of microtubule assembly. Podophyllum hexandrum royle of family berberidaceae is an endangered medicinal plant. Podophyllum peltatum contains 45% podophyllum resin, whereas p. Podophyllum resin definition of podophyllum resin by. Use always apply a protective layer of vaseline or zinc oxide ointment on the surrounding skin prior to treatment. Podophyllum resin, topical pohdoffilum rezin what are other names for this medicine. Podophyllum resin article about podophyllum resin by the.
About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Applying podophyllum resin, also called podophyllin, as a 10% to 25% suspension in tincture of benzoin or as a 2% to 4% gel directly to the affected area is effective for the removal of warts. Podophyllum resin, usp 9000559 po105 spectrum chemical. Also, keep podophyllum away from the eyes and other mucous membranes, such as the inside of the nose, mouth, or vagina. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Podophyllin is a resin extracted from the roots of podophyllum peltatum american mandrake and podophyllum emodi, which contains numerous compounds, amongst which is podophyllin as well as the drug podophyllotoxin. In the great continental divorce about 250 million years ago, most of the really cool mayapple species were on the wrong side of the great crack and got stuck in china. Podophyllin from podophyllum emodii powder podophyllum resin. The child has profuse, gushing diarrhea that is watery, green or yellow, and offensive. Application by a healthcare provider to the skin is recommended. Podophyllum resin is a poison by ingestion, subcutaneous, and intraperitoneal routes. Podophyllum resin, also known as podophyllum or podophyllin, is a resin made from the roots of the american mandrake. It is used as starting compound for the synthesis of anticancer drug etoposide and teniposide.
Often the diarrhea is painless, although some cramping may. If you have an allergy to podophyllum or any other part of podophyllum resin. Podophyllum peltatun mayapple berberidaceae environmental. The upper part of the stem bears two large, opposite, and longpetioled palmatipartite leaves and one drooping white flower measuring. Here, you can learn more about these chemicals and what you can do to reduce your exposure for a healthier pregnancy. Pdf extraction studies of podophyllum hexandrum using. Intoxications with podophyllin have resulted in peripheral neurological sideeffects such as autonomic neuropathy, sensorimotor peripheral neuropathy, and acute ataxic sensory neuronopathy filley et al. It is particularly noticeable that ptox is the most abundant lignan in podophyllin, a resin produced by species of the genus podophyllum and some endophytic microorganisms in cupressaceae family kusari et al. The variation in percentage of resin is attributed to seasonal differences, different sites of growth and age of the plant. Podophyllum is an herbaceous perennial plant in the family berberidaceae, described as a genus by linnaeus in 1753. Find patient medical information for podophyllum resin bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Epoxies and resins are chemicals that can form a hard, strong.
Podophyllum resin is prepared from rhizomes and roots of certain plants, including podophyllum peltatum known as american mandrake, may apple, ducks foot, indian apple. From a single stem, each plant grows 1218 tall and features one or two, deeplydivided, palmatelylobed, umbrellalike, pale green leaves to 12 diameter. Nov 09, 2018 podophyllum resin is made from the extracts of certain plants such as american mandrake, may apple, ducks foot, indian apple. Use 1025% solution for areas podophyllum resin contact with eyes or similar mucosal surfaces. Podophyllum a genus of plants of the family podophyllaceae. Large areas and numerous warts should not be treated at 1 time. Podphyllotoxin is the most active cytotoxic natural product. The rhizome of the plant contains a resin, known generally and commercially as indian podophyllum resin, which can be processed to extract podophyllotoxin or. This page was last edited on 16 december 2019, at 19.
Podophyllin definition is a resin obtained from podophyllum and used in medicine as a caustic. Podophyllum hexandrum royle is an important medicinal plant known for valuable drug podophylotoxin which is effective against various diseases. Podophyllum article about podophyllum by the free dictionary. To learn more about this unique herbaceous perennial, read this article. Your doctor may want to give your first dose of this medicine in a clinic setting to quickly treat any serious side effects that occur. Podophyllum contains 45% podophyllum resin, whereas indian sps. The purgative properties of podophyllum peltatum may apple root were known to the american indian before the time of the white man. Podophyllum resin chemical properties,uses,production. Selftreatment of condylomata acuminata with podophyllin resin. Podophyllum resin manufacturer, supplier,buy 9000559. The genus podophyllum consists of low perennial herbs that have a long, creeping rootstock.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Podocon25, pododerm, podofin podophyllum resin topical. Firefighting measures suitable extinguishing agents. Podophyllum peltatum is the only species in this genus in the barberry family berberidaceae. Cas no9000559 podophyllum resin supplier, for sale from chinese manufacturer on biotain pharma co. Nov 16, 2016 seair exim solutions provides complete details of podophyllum resin exports from india. All structured data from the file and property namespaces is available under the creative commons cc0 license. The drugs may be distinguished chemically by adding a few drops of strong solution of copper acetate to a filtered alcoholic extract prepared from each. Material safety data sheet according to iso 110141. There is gurgling in the abdomen with passage of gas. Podophyllum resin is a powdered mixture of resins extracted from the roots of podophyllum pelltatum. If youve only seen our native podophyllum peltatum, you have missed some of the great joys of the genus podophyllum. Podophyllum peltatum is one of the main medicines for acute diarrhea in children.
Podophyllin definition of podophyllin by merriamwebster. Sep 17, 2019 early research suggests that a single application of 25% podophyllum resin in tincture of benzoin to the affected area can help heal wounds caused by hairy leukoplakia. Lower concentrations of american podophyllum resin in alcoholic solutions have been used. Podophyllum resin manufacturer, supplier,buy 9000559 bulk. Use alcohol foam, co 2, or dry chemical to fight fire. All spectrum chemical usp grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. The podophyllin resin used in this product is exclusively the american podophyllin rather than the indian resin. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Remove the dried resin with alcohol or soap and water. Podophyllum resin topical is not for use inside the vagina, cervix, rectum, or. Mayapple is a native wildflower with distinctive, deeply lobed, umbrellashaped leaves.
Pdf podophyllum hexandrum a versatile medicinal plant. This medicine may be used to treat other conditions as. The highest percentage of resin is obtained in mayjune. Podophyllum resin, also known as podophyllum or podophyllin, is a resin made from the roots. Stronger doses of podophyllum resin topical must be applied by a healthcare professional and not at home. Mayapple is a native woodland plant that is widespread across most of eastern north america south to texas in zones 3 to 8. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Thereafter, lesional contact should be kept to the minimum time to produce the desired result 1 to 4 hours. Freshly collected rhizomes are reported to contain higher quantity of active principles which may be lost on prolonged storing. Formulas about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding.
Podocon25 podophyllin side effects, images, uses, dosage. Podophyllum pleianthum, commonly called chinese mayapple, is native to central and southeastern china. Podophyllum peltatun mayapple berberidaceae the mayapple is an herbaceous perennial plant native to deciduous forests of eastern north america. Files are available under licenses specified on their description page.
Topical treatment of genital warts condylomata acuminata. In the past, several species were included in the genus, but all but one have been transferred to other genera dysosma and sinopodophyllum. Podophyllum resin is usually formulated in compound benzoin tincture in strengths of 15% indian podophyllum resin or 10 to 25% american podophyllum resin. It is not recommended in hpv infections without external warts. View picture of podophyllum, hybrid mayapple spotty dotty podophyllum at daves garden. Dec 07, 2019 if you get podophyllum resin in the eyes, flush right away with cool water and get medical help.
This medicine is for use only on warts outside the genitals and around the outside of the anus. Jun 04, 2019 what is podophyllum resin topical podocon25, pododerm, podofin. Aug 22, 2019 podophyllum resin is prepared from rhizomes and roots of certain plants, including podophyllum peltatum known as american mandrake, may apple, ducks foot, indian apple. Podophyllum resin in alcohol or compound benzoin tincture, 10%, 15% and 25% solution for topical application.